LATIDIA · Ciberseguridad

Factibilidad de la inferencia homomórfica para un modelo de base genómica

arXiv:2609.16211v1 Tipo de anuncio: nuevo Resumen: Las secuencias genómicas humanas pueden identificar individuos, no se pueden reemplazar después de la divulgación y son los insumos que los modelos de fundación genómica están diseñados para interpretar. Evaluamos

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arXiv:2609.16211v1 Announce Type: new Abstract: Human genomic sequences can identify individuals, cannot be replaced after disclosure, and are the inputs that genomic foundation models are designed to interpret. We assess whether a compute provider can execute a released genomic foundation model without receiving query-derived genomic values in plaintext and whether correctness, memory, or cost prevents complete encrypted inference. We first reproduce the released model on three genomic task families and freeze an independently validated numerical reference. We then implement a client-assisted approximate homomorphic encryption protocol: the provider evaluates linear algebra on ciphertexts, while the key-holding data owner evaluates exact normalization, causal softmax, and activation functions at fixed boundaries. A noninteractive